Phenotypes Associated with This Genotype

Genotype
MGI:2681434

• Allelic Composition: Prkn^tm1Shn/Prkn^tm1Shn
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:86377 )

• poorer performance in various measures of motor performance

• rotarod performance was normal

nervous system

abnormal nervous system electrophysiology ( J:86377 )

• higher currents are required in striatal neurons to trigger synaptic response

homeostasis/metabolism

increased dopamine level ( J:86377 )

• higher than normal levels of dopamine in the striatum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 2		DOID:0060368	OMIM:600116	J:86377