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Phenotypes Associated with This Genotype
Genotype
MGI:2681790
ht3
Allelic
Composition
Rps20Mhdadsk4/Rps20+
Genetic
Background
C3HeB/FeJ-Rps20Mhdadsk4/Ieg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps20Mhdadsk4 mutation (1 available); any Rps20 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
• adults show excess epidermal pigmentation in the footpads, tail and ears
• excess pigment with a brown hue distributed in small patches on all or most of the volar pads identifiable at approximately 6 weeks of age (J:86685)
• increased footpad pigmentation is seen by 3 weeks of age and persists throughout adult life; pigment accumulates in the footpad epidermis (J:139244)
• Kitl (kit ligand) mRNA levels are increased in the footpad epidermis relative to control mice (J:139244)
• increased Trp53 staining is noted in the adult footpad epidermis relative to control mice (J:139244)
• increased tail pigmentation is seen by 3 weeks of age and persists throughout adult life
• pigment accumulates in the adult tail epidermis, whereas the dermis is unaffected

integument
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
• adults show excess epidermal pigmentation in the footpads, tail and ears
• excess pigment with a brown hue distributed in small patches on all or most of the volar pads identifiable at approximately 6 weeks of age (J:86685)
• increased footpad pigmentation is seen by 3 weeks of age and persists throughout adult life; pigment accumulates in the footpad epidermis (J:139244)
• Kitl (kit ligand) mRNA levels are increased in the footpad epidermis relative to control mice (J:139244)
• increased Trp53 staining is noted in the adult footpad epidermis relative to control mice (J:139244)
• increased tail pigmentation is seen by 3 weeks of age and persists throughout adult life
• pigment accumulates in the adult tail epidermis, whereas the dermis is unaffected

limbs/digits/tail
• excess pigment with a brown hue distributed in small patches on all or most of the volar pads identifiable at approximately 6 weeks of age (J:86685)
• increased footpad pigmentation is seen by 3 weeks of age and persists throughout adult life; pigment accumulates in the footpad epidermis (J:139244)
• Kitl (kit ligand) mRNA levels are increased in the footpad epidermis relative to control mice (J:139244)
• increased Trp53 staining is noted in the adult footpad epidermis relative to control mice (J:139244)
• increased tail pigmentation is seen by 3 weeks of age and persists throughout adult life
• pigment accumulates in the adult tail epidermis, whereas the dermis is unaffected

growth/size/body
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life

craniofacial
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life

hearing/vestibular/ear
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory