Phenotypes Associated with This Genotype

Genotype
MGI:2683230

• Allelic Composition: Stat3^tm1Flv/Stat3^tm1Flv; Tg(Tek-cre)1Xyfu/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine secretion ( J:86655 )

• LPS elicits increased and prolonged proinflammatory cytokine production, with increases in TNF-alpha, IL-6, IFN-gamma, and IL-10

increased susceptibility to endotoxin shock ( J:86655 )

• increased lethality after LPS challenge, with exaggerated inflammation and leukocyte infiltration in multiple organs

• organ damage indicated by increased serum alanine and aspartate aminotransferase activities

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
inflammatory bowel disease		DOID:0050589	OMIM:PS266600	J:86655