Phenotypes Associated with This Genotype

Genotype
MGI:2683647

• Allelic Composition: Icos^tm1Flv/Icos^tm1Flv
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:87123 )

N • T lymphocyte development normal in the thymus

abnormal immunoglobulin level ( J:87123 )

decreased IgE level ( J:87123 )

• production of IgE reduced

decreased IgG1 level ( J:87123 )

• reduction of IgG1 levels

abnormal T-helper 2 physiology ( J:87123 )

• defect indicated by low Il-4 levels and low IgG1 and IgE levels

• Th2 differentiation normal but function disrupted

abnormal interferon level ( J:87123 )

• Ifn-gamma levels were normal to slightly increased

abnormal interleukin level ( J:87123 )

• Il-2 production defective

• Il-4 production very low

• Il-10 levels normal

• Il-13 levels reduced

small lymph nodes ( J:87123 )

• lymph nodes were small in immunized mice

• about 1/2 as many cells/node as in wild-type mice

increased susceptibility to experimental autoimmune encephalomyelitis ( J:87123 )

• greater succeptibility to experimental autoimmune encephalitis

homeostasis/metabolism

abnormal interferon level ( J:87123 )

• Ifn-gamma levels were normal to slightly increased

abnormal interleukin level ( J:87123 )

• Il-2 production defective

• Il-4 production very low

• Il-10 levels normal

• Il-13 levels reduced

hematopoietic system

abnormal immunoglobulin level ( J:87123 )

decreased IgE level ( J:87123 )

• production of IgE reduced

decreased IgG1 level ( J:87123 )

• reduction of IgG1 levels

abnormal T-helper 2 physiology ( J:87123 )

• defect indicated by low Il-4 levels and low IgG1 and IgE levels

• Th2 differentiation normal but function disrupted

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
common variable immunodeficiency		DOID:12177	OMIM:PS607594	J:87123