Phenotypes Associated with This Genotype

Genotype
MGI:2684307

• Allelic Composition: F13a1^tm1Gdi/F13a1^tm1Gdi
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Altered response to myocardial infraction in F13a1^tm1Gdi/F13a1^tm1Gdi mice

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:121502 , J:129358 )

• all die within 5 days after myocardial infarction from left ventricular rupture (J:121502)

• daily intravenous replenishment of F13a1 for 5 days restores survival (J:121502)

pregnancy-related premature death ( J:86919 )

♀

cardiovascular system

hemothorax ( J:86919 )

• observed in some male mice

uterine hemorrhage ( J:86919 , J:129358 )

• following myocardial infarction, intrathoracic hematoma is seen adjacent to the experimental anterolateral infarction (J:129358)

♀ • intrauterine bleeding (J:86919)

abnormal response to cardiac infarction ( J:121502 , J:129358 )

• mutants subjected to coronary ligation die within 5 days and exhibit hemothorax, myocardial rupture of the left ventricular wall, and reduced inflammatory response in the infarct (J:121502)

reproductive system

uterine hemorrhage ( J:86919 , J:129358 )

• following myocardial infarction, intrathoracic hematoma is seen adjacent to the experimental anterolateral infarction (J:129358)

♀ • intrauterine bleeding (J:86919)

reduced female fertility ( J:86919 )

♀ • intrauterine fetal death due to placental hemorrhage

respiratory system

hemothorax ( J:86919 )

• observed in some male mice

homeostasis/metabolism

abnormal response to cardiac infarction ( J:121502 , J:129358 )

• mutants subjected to coronary ligation die within 5 days and exhibit hemothorax, myocardial rupture of the left ventricular wall, and reduced inflammatory response in the infarct (J:121502)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
factor XIII deficiency		DOID:2211	OMIM:613225 OMIM:613235	J:86919