Phenotypes Associated with This Genotype

Genotype
MGI:2684461

• Allelic Composition: Twist1^Pas/Twist1⁺
• Genetic Background: involves: C57BL/6 * PDT/Pas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Polydactyly in the right hindlimb of Twist1^Pas/Twist1⁺ mice

craniofacial

cleft palate ( J:86815 )

• cleft palate and other defects related to craniogenesis are observed approximately 5 % of the time and always in conjunction with polydactyly

limbs/digits/tail

polydactyly ( J:86815 )

• alterations in pattern development leads to the formation of one, but rarely two extra digits in the preaxial part of one of the hindlimbs, rarely both without left right preference

• penetrance varies with genetic background but is never complete

• genetic analysis reveals that this allele is sufficient to produce the polydactyly phenotype at a low frequency

digestive/alimentary system

cleft palate ( J:86815 )

• cleft palate and other defects related to craniogenesis are observed approximately 5 % of the time and always in conjunction with polydactyly

growth/size/body

cleft palate ( J:86815 )

• cleft palate and other defects related to craniogenesis are observed approximately 5 % of the time and always in conjunction with polydactyly

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Saethre-Chotzen syndrome		DOID:14768	OMIM:101400 OMIM:180750	J:86815