Phenotypes Associated with This Genotype

Genotype
MGI:2686810

• Allelic Composition: Tg(Rho)1Wbae/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Temporal progressive retinal changes in normal and Tg(Rho)1Wbae/0 mice

vision/eye

abnormal retina morphology ( J:12791 )

decreased retina photoreceptor cell number ( J:12791 )

• progressive reduction of both rod and cone photoreceptors with age

short photoreceptor outer segment ( J:12791 )

• light-sensitive outer segments are about 50% of normal length by P20 and continue to shorten over time

retina photoreceptor degeneration ( J:12791 )

• slow degeneration that progresses over 50% of the lifetime of a normal mouse

• associated with a decrease in light-evoked electroretinogram response

retina cone cell degeneration ( J:12791 )

retina rod cell degeneration ( J:12791 )

thin retina outer nuclear layer ( J:12791 )

• reduction in thickness of the outer nuclear layer

abnormal eye electrophysiology ( J:12791 )

• ERGs from dark-adapted mutants show a significant reduction in teh amplitudes of a and b waves at P30

• between P30 and P210, the a wave gradually decreases and the b wave is reduced to about 30% of normal

nervous system

decreased retina photoreceptor cell number ( J:12791 )

• progressive reduction of both rod and cone photoreceptors with age

short photoreceptor outer segment ( J:12791 )

• light-sensitive outer segments are about 50% of normal length by P20 and continue to shorten over time

retina photoreceptor degeneration ( J:12791 )

• slow degeneration that progresses over 50% of the lifetime of a normal mouse

• associated with a decrease in light-evoked electroretinogram response

retina cone cell degeneration ( J:12791 )

retina rod cell degeneration ( J:12791 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 4		DOID:0110372	OMIM:613731	J:12791