Phenotypes for Hfe Urod MGI:2687183 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hfe^tm2Nca/Hfe^tm2Nca Urod^tm1Kush/Urod⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfe^tm2Nca mutation (1 available); any Hfe mutation (35 available)
Urod^tm1Kush mutation (0 available); any Urod mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased liver iron level ( J:66704 )

increased porphyrin level ( J:66704 )

• increased urinary porphyrin concentration (hepatic levels were also increased)

liver/biliary system

increased liver iron level ( J:66704 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
porphyria cutanea tarda		DOID:3132	OMIM:176090 OMIM:176100	J:66704

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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