Phenotypes Associated with This Genotype

Genotype
MGI:3026664

• Allelic Composition: Vegfc^tm1Ali/Vegfc⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

lymphedema ( J:87394 )

• accumlulation of chylous, milky fluid high in triglycerides in the abdomen

• adults show swelling of the paws

chylous ascites ( J:87394 )

• the stagnant chylous ascites produces an inflammatory response in the abdominal cavity and leads to severe adhesions and fibrosis of the internal organs

immune system

abnormal lymph circulation ( J:87394 )

• cutaneous lymphatic vessels do not uptake dextran as seen in wild-type vessels

• no lymphatic fluid transport of Evans blue dye is observed into the collecting lymphatic vessles after intradermal injection of dye to the hind limbs

lymphatic vessel hypoplasia ( J:87394 )

• severe but transient hypoplasia of the lymphatic vasculature in newborns

cardiovascular system

abnormal lymph circulation ( J:87394 )

• cutaneous lymphatic vessels do not uptake dextran as seen in wild-type vessels

• no lymphatic fluid transport of Evans blue dye is observed into the collecting lymphatic vessles after intradermal injection of dye to the hind limbs

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary lymphedema		DOID:0050580	OMIM:PS153100	J:209628