Phenotypes Associated with This Genotype

Genotype
MGI:3027071

• Allelic Composition: Pklr^char4/Pklr^char4
• Genetic Background: involves: A/J * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:141722 )

• in mice infected with malaria parasite P. chabaudi

hematopoietic system

enlarged spleen ( J:86735 )

• splenomegaly resulting from hemolytic anemia due to pyruvate kinase deficiency

anemia ( J:141722 )

• less severe than in Pklr^char4 homozygotes

hemolytic anemia ( J:86735 )

abnormal erythrocyte morphology ( J:86735 )

• constitutive erythropoeisis resulting from hemolytic anemia due to pyruvate kinase deficiency

abnormal erythropoiesis ( J:141722 )

• increased

decreased hemoglobin content ( J:141722 )

reticulocytosis ( J:86735 , J:141722 )

• resulting from hemolytic anemia due to pyruvate kinase deficiency (J:86735)

increased erythrocyte clearance ( J:141722 )

immune system

enlarged spleen ( J:86735 )

• splenomegaly resulting from hemolytic anemia due to pyruvate kinase deficiency

decreased susceptibility to parasitic infection ( J:86735 , J:141722 )

• resistance to malaria infection has been observed in congenic strains carrying malaria susceptibility alleles for 2 other QTL (J:86735)

• an inverse relationship exists between malarial parasite load and reticulocyte count (J:86735)

• mice infected with the malaria parasite Plasmodium chabaudi AS exhibit lower parasitemia and no mortality unlike control mice (J:141722)

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:141722 )

• in mice infected with malaria parasite P. chabaudi

growth/size/body

enlarged spleen ( J:86735 )

• splenomegaly resulting from hemolytic anemia due to pyruvate kinase deficiency

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malaria		DOID:12365		J:86735 , J:141722
pyruvate kinase deficiency of red cells		DOID:0111077	OMIM:266200	J:86735