Phenotypes Associated with This Genotype

Genotype
MGI:3027982

• Allelic Composition: Slc4a1^wan/Slc4a1^wan
• Genetic Background: C3H/HeJ-Slc4a1^wan/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:85321 )

• animals die by 72 hours of age

hematopoietic system

anemia ( J:85321 )

abnormal erythroblast morphology ( J:85322 )

• presence of binucleated erythroblasts at 14% compared to 2% in wild-type

decreased erythrocyte cell number ( J:85321 )

• fetal counts are decreased at E15-E18

decreased hematocrit ( J:85321 )

decreased hemoglobin content ( J:85321 )

decreased mean corpuscular volume ( J:85321 )

spherocytosis ( J:85321 )

• cells have occasional membrane extensions

reticulocytopenia ( J:85321 )

• reticulocytes are decreased in number by E15 and are absent thereafter

cellular

binucleate ( J:85322 )

• presence of binucleated erythroblasts at 14% compared to 2% in wild-type

integument

pallor ( J:85321 )

• animals are noticeably pale at birth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary spherocytosis type 4		DOID:0110919	OMIM:612653	J:89043