Phenotypes Associated with This Genotype

Genotype
MGI:3028002

• Allelic Composition: Pde6b^atrd2/Pde6b^rd1
• Genetic Background: involves: BALB/cAnN * C3H/HeN

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina morphology ( J:101336 )

• patches of pigmented cells are seen at 3.5 weeks of age

thin retina outer nuclear layer ( J:101336 )

• progressive loss of cell layers

retina degeneration ( J:75964 , J:101336 )

• slow onset of degeneration; the visual tracking response persists until several weeks of age in contrast to Pde6b^rd1 homozygous mice (J:75964)

• patches of pigmented cells are seen at 3.5 weeks of age (J:101336)

decreased visual acuity ( J:101336 )

• at 3.5 weeks of age, no mice respond to a 2 degree grating and 40% respond to a 4 degree grating in a visual tracking drum assay

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital stationary night blindness autosomal dominant 2		DOID:0110863	OMIM:163500	J:75964
retinitis pigmentosa 40		DOID:0110375	OMIM:613801	J:101336