Phenotypes Associated with This Genotype

Genotype
MGI:3028504

hm4

• Allelic Composition: Hoxa5^tm1Rob/Hoxa5^tm1Rob
• Genetic Background: involves: 129S/SvEv * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:15576 )

• proportions of homozygotes normal at E18.5

• most deaths within 4 days after birth

• survivors lack overt phenotype and are fertile

skeleton

increased sternebra number ( J:15576 )

• extra sternebrae in 9% of homozygotes, develops from manubrium

sternebra fusion ( J:15576 )

• some cases of fusion of adjacent sternebrae

asymmetric sternocostal joints ( J:15576 )

• irregularities in sternocostal attachments

abnormal rib morphology ( J:15576 )

increased rib number ( J:15576 )

• C7 rib development extensive on one or both sides

• L1 ribs in 19% of individuals

rib fusion ( J:15576 )

• one third of C7 ribs were fused ventrally with first thoracic rib but occasionally make independent contact with sternum

abnormal vertebrae morphology ( J:15576 )

cervical vertebral transformation ( J:15576 )

• C7 ribs in 73% of homozygotes at birth

• percent of C7 ribs lower in homozygotes surviving to adulthood

• absence of tuberulum anterior on C6 making it more similar to C3, C4, C5

lumbar vertebral transformation ( J:15576 )

• L1 ribs in 19% of individuals