Phenotypes Associated with This Genotype

Genotype
MGI:3028886

hm1

• Allelic Composition: Tec^tm1Welm/Tec^tm1Welm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased platelet aggregation ( J:86448 )

• minor reduction in aggregation in response to threshold concentrations of collagen-related peptide (CRP) and to collagen; higher doses overcome these effects

• no alterations in aggregation in response to ADP

immune system

immune system phenotype ( J:66080 )

N • no developmental alterations in T or B cell populations

N • number of splenic T and B cells similar to littermate controls

N • B cell activation by either anti-IgM Ab or LPS was similar to that of B cells from littermate controls

homeostasis/metabolism

decreased platelet aggregation ( J:86448 )

• minor reduction in aggregation in response to threshold concentrations of collagen-related peptide (CRP) and to collagen; higher doses overcome these effects

• no alterations in aggregation in response to ADP