Phenotypes Associated with This Genotype

Genotype
MGI:3029285

• Allelic Composition: Tg(APPSWE)2576Kha/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:180385 )

N • 12 month old mice exhibit normal motor coordination on the rotarod

abnormal eye blink conditioning behavior ( J:180385 )

• mutants exhibit impaired long-trace interval eyeblink conditioning at 6 months of age

• however, mutants do not exhibit impaired delay eyeblink conditioning even at 12 months of age, although it is slightly but insignificantly decreased

abnormal spatial learning ( J:114480 )

• impaired spatial learning in a morris water maze

abnormal long-term spatial reference memory ( J:114480 )

• in a probe trial mice fail to occupy the target quadrant longer than chance indicating memory retention deficits

decreased anxiety-related response ( J:114480 )

• spend more time in the open arms of an elevated plus maze

hyperactivity ( J:114480 )

homeostasis/metabolism

amyloidosis ( J:114480 )

amyloid beta deposits ( J:76863 , J:114480 )

• increase in insoluble amyloid beta and plaques with aging; greater increase in plaques in females than males (J:76863)

increased brain zinc level ( J:76863 )

• females exhibit an increase in levels of synaptic zinc with aging

nervous system

amyloid beta deposits ( J:76863 , J:114480 )

• increase in insoluble amyloid beta and plaques with aging; greater increase in plaques in females than males (J:76863)

increased brain zinc level ( J:76863 )

• females exhibit an increase in levels of synaptic zinc with aging

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:114480 , J:180385