Phenotypes Associated with This Genotype

Genotype
MGI:3029380

• Allelic Composition: Slc2a2^tm1Thor/Slc2a2^tm1Thor
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:43839 )

• died at 2-3 weeks of age

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:43839 )

increased pancreatic alpha cell mass ( J:43839 )

• volume density increased 50% as glucagon expression increased

decreased pancreatic beta cell mass ( J:43839 )

• volume density of beta cells decreased 30%

decreased pancreas weight ( J:43839 )

• pancreas weight dropped about 25% by day 15

growth/size/body

decreased body weight ( J:43839 )

• growth was normal for first 6 days

• failed to thrive thereafter

• body weight down 35% by day 15

homeostasis/metabolism

increased blood osmolality ( J:43839 )

• blood osmolality increased to 420 mosmol/l

abnormal glucose homeostasis ( J:43839 )

hyperglycemia ( J:43839 )

• moderately hyperglycemic at day 15

increased circulating glucagon level ( J:43839 )

• glucagons levels were markedly increased at 15 days of age

decreased circulating insulin level ( J:43839 )

• relatively hypoinsulinemic at day 15

• glucose stimulated insulin secretion did not occur

• no buildup of insulin mRNA in beta cells

abnormal glucose tolerance ( J:43839 )

• in an oral glucose tolerance test, a sharp rise in glucose occurred

• hyperglycemia persisted longer than in controls

• basal glucose levels were elevated

abnormal lipid homeostasis ( J:43839 )

increased fatty acids level ( J:43839 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:43839