Phenotypes Associated with This Genotype

Genotype
MGI:3032575

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Tg(Pdx1-cre)6Tuv/?
• Genetic Background: involves: 129S4/SvJae * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:87973 )

• transitions of epithelium from cuboid to columnar as early as 2 weeks

• number and extent of lesions increases with age

• by 7-10 months occasional animals with invasive and metastatic adenocarcinomas

• lesions eventually found in liver diaphragm and lungs

endocrine/exocrine glands

enlarged pancreas ( J:87973 )

increased pancreatic ductal adenocarcinoma incidence ( J:87973 )

• transitions of epithelium from cuboid to columnar as early as 2 weeks

• number and extent of lesions increases with age

• by 7-10 months occasional animals with invasive and metastatic adenocarcinomas

• lesions eventually found in liver diaphragm and lungs

growth/size/body

enlarged pancreas ( J:87973 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:87973