Phenotypes Associated with This Genotype

Genotype
MGI:3032576

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:87973 )

increased pancreatic ductal adenocarcinoma incidence ( J:87973 , J:116130 )

• pancreatic ductal adenocarcinomas (J:87973)

• transitions of epithelium from cuboid to columnar as early as 2 weeks (J:87973)

• extra pancreatic tumors are rare (J:87973)

• number and extent of lesions increases with age (J:87973)

• by 7-10 months occasional animals with invasive and metastatic adenocarcinomas (J:87973)

• lesions eventually found in liver diaphragm and lungs (J:87973)

• average cancer free survival is greater than 52 weeks and 2 of 9 mice develop pancreatic ductal adenocarcinoma (J:116130)

increased pancreatic intraepithelial neoplasia incidence ( J:262746 )

• pancreatic intraepithelial neoplasia (PanIN)-1 lesions are distributed widely throughout the pancreas, whereas PanIN-2 or -3 lesions are rarely seen

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:262746 )

• 6 month old mice exhibit mild acinar cell loss

endocrine/exocrine glands

abnormal pancreatic acinar cell morphology ( J:262746 )

• 6 month old mice exhibit mild acinar cell loss

enlarged pancreas ( J:87973 )

increased pancreatic ductal adenocarcinoma incidence ( J:87973 , J:116130 )

• pancreatic ductal adenocarcinomas (J:87973)

• transitions of epithelium from cuboid to columnar as early as 2 weeks (J:87973)

• extra pancreatic tumors are rare (J:87973)

• number and extent of lesions increases with age (J:87973)

• by 7-10 months occasional animals with invasive and metastatic adenocarcinomas (J:87973)

• lesions eventually found in liver diaphragm and lungs (J:87973)

• average cancer free survival is greater than 52 weeks and 2 of 9 mice develop pancreatic ductal adenocarcinoma (J:116130)

increased pancreatic intraepithelial neoplasia incidence ( J:262746 )

• pancreatic intraepithelial neoplasia (PanIN)-1 lesions are distributed widely throughout the pancreas, whereas PanIN-2 or -3 lesions are rarely seen

growth/size/body

enlarged pancreas ( J:87973 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:87973