Phenotypes Associated with This Genotype

Genotype
MGI:3033164

• Allelic Composition: Cpe^fat/Cpe^fat
• Genetic Background: involves: HRS/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:10872 )

• noted in all adipose tissue of the body

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:10872 )

degranulated pancreatic beta cells ( J:13651 )

• some degranulation of beta cells was noted

increased pancreatic islet number ( J:13651 )

• increased numbers of islets noted

pancreatic islet hyperplasia ( J:10872 )

• hypertrophy and hyperplasia of islets noted

growth/size/body

obese ( J:10872 , J:13651 )

• abnormal amounts of fat by 4-5 weeks of age; progressive with age; homozygotes weigh up to 60-70 grams by 6-8 months of age (J:13651)

homeostasis/metabolism

hypoglycemia ( J:13651 )

• fluctuations in blood sugar concentrations occur; concentrations of less than 100mg/100ml are common in animals older than 6 months

hyperglycemia ( J:10872 )

• transient hyperglycemia noted in males at 7-8 weeks of age

increased circulating insulin level ( J:10872 , J:13651 )

• severe at weaning age (J:10872)

reproductive system

infertility ( J:10872 )

• noted in older mice; mice are not sterile; homozygous mice can produce litters if mated before the onset of obesity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:10872 , J:13651