mortality/aging
• life span is normal on a normal diet
• death occurs after 3-4 weeks on a thiamin deficient diet
|
cellular
azoospermia
(
J:87410
)
• no sperm in the epididymis at 12 weeks of age
|
• absent
|
• no metaphase I or metaphase II germ cells seen
• severely reduced number of mid pachytene spermatocytes
• on a thiamin deficient diet, spermatocyte loss occurred at an even earlier stage
|
behavior/neurological
• after 4-5 weeks on a normal diet
• after about 17 days on a thiamin deficient diet
|
reproductive system
• half normal weight
• many apoptotic cells in the tubules
|
• completely disrupted
|
azoospermia
(
J:87410
)
• no sperm in the epididymis at 12 weeks of age
|
• absent
|
• no metaphase I or metaphase II germ cells seen
• severely reduced number of mid pachytene spermatocytes
• on a thiamin deficient diet, spermatocyte loss occurred at an even earlier stage
|
• on any diet
• male fertility was totally restored by a minimum of 20 days on a high thiamin diet
|
hearing/vestibular/ear
• normal auditory-evoked brainstem response on a normal diet
• hearing loss on a thiamin deficient diet
• recovery from hearing loss after restoration of thiamin to the diet in 2 out of 3 mice
|
hematopoietic system
• dysplastic hematopoiesis and reversed myeloid to erythroid ratio
|
• dyssynchrony of nuclear and cytoplasmic maturation
• increase in early erythroid precursors and oversized cells at all stages
|
• larger cells
• increased lobulation of megakaryocyte nuclei
|
homeostasis/metabolism
• impaired insulin secretion with thiamin deficiency
|
• after 17 days without dietary thiamin, glucose intolerant as determined in a glucose tolerance test
• blood glucose still elevated 120 min into test
• glucose intolerance is resolved 6 weeks after reintroduction of thiamin to diet
|
• prolonged hypoglycemic response in an insulin tolerance
|
immune system
• larger cells
• increased lobulation of megakaryocyte nuclei
|
endocrine/exocrine glands
• half normal weight
• many apoptotic cells in the tubules
|
digestive/alimentary system
N |
• thiamin uptake is normal
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
thiamine-responsive megaloblastic anemia syndrome | DOID:0090117 |
OMIM:249270 |
J:79974 |