Phenotypes Associated with This Genotype

Genotype
MGI:3033701

hm3

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp
• Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:88365 )

• few survive over a year of age due to spontaneous tumors

neoplasm

increased tumor incidence ( J:88365 )

increased lymphoma incidence ( J:88365 )

• 90% of spontaneous tumors that develop in mutants are histiocytic lymphomas involving the spleen, peripancreatic and other lymph nodes or other sites

increased sarcoma incidence ( J:88365 )

• 9% of tumors that develop in mutants are malignant spindle cell neoplasms, most likely soft-tissue sarcomas

cellular

abnormal cell physiology ( J:88365 )

• MEFs are susceptible to oncogenic transformation, show enhanced subcloning efficiency at low density, and resist both RAS- and culture-induced growth arrest