Phenotypes Associated with This Genotype

Genotype
MGI:3036311

• Allelic Composition: Ddb2^tm1Linn/Ddb2⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tumorigenesis analysis and Hisptopathological images

neoplasm

increased incidence of tumors by UV-induction ( J:88125 )

• mutants treated with UV light develop skin tumors at a similar time as wild-type, however once tumors form, tumor development proceeds at a greater rate and mice develop more tumors than controls

integument

increased sensitivity to skin irradiation ( J:88125 )

• increased incidence of skin tumors after UV-irradiation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
xeroderma pigmentosum group E		DOID:0110846	OMIM:278740	J:88125