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Phenotypes Associated with This Genotype
Genotype
MGI:3036450
cn12
Allelic
Composition		 Foxa2tm1Khk/Foxa2tm1Khk
Tg(Scgb1a1-rtTA)1Jaw/0
Tg(tetO-cre)1Jaw/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxa2tm1Khk mutation (1 available); any Foxa2 mutation (28 available)
Tg(Scgb1a1-rtTA)1Jaw mutation (3 available)
Tg(tetO-cre)1Jaw mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:88601 )
N
• no increase in the number of neutrophils or macrophages in mice treated with doxycycline from E0 through P16

respiratory system
increased respiratory mucosa goblet cell number ( J:88601 )
• goblet cell hyperplasia, associated with the accumulation of both neutral and acidic mucins, in the larger airways of mice treated with doxycycline from E0 through P16
• neither airspace nor alveolar morphological abnormalities were detected
increased airway resistance ( J:88601 )
• increased in mice treated with doxycycline
decreased lung compliance ( J:88601 )
• decreased in mice treated with doxycycline

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory
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