Phenotypes Associated with This Genotype

Genotype
MGI:3036851

hm1

• Allelic Composition: Sim1^tm1Fan/Sim1^tm1Fan
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:50772 )

• homozygotes survived to birth but died within the first 24 hours after birth

endocrine/exocrine glands

absent magnocellular neurosecretory cells ( J:50772 )

abnormal pituicyte morphology ( J:50772 )

• absence of axonal projections from the paraventricular and supraoptic nuclei results in more densly packed pituicytes in the posterior lobe of the pituitary

pituitary gland hypoplasia ( J:50772 )

• average number of cells in midsagittal sections of the pituitary are reduced by about 50%

nervous system

abnormal diencephalon morphology ( J:50772 )

• paraventricular nucleus and supraoptic nuclei are hypocellular

• magnocellular neurons are absent

• terminal differentiation of neurons in both nuclei fails

absent magnocellular neurosecretory cells ( J:50772 )

abnormal pituicyte morphology ( J:50772 )

• absence of axonal projections from the paraventricular and supraoptic nuclei results in more densly packed pituicytes in the posterior lobe of the pituitary

pituitary gland hypoplasia ( J:50772 )

• average number of cells in midsagittal sections of the pituitary are reduced by about 50%

abnormal paraventricular hypothalamic nucleus morphology ( J:50772 )

• hypocellular

• absence of axonal projections from the paraventricular nuclei

abnormal supraoptic nucleus morphology ( J:50772 )

• hypocellular

• absence of axonal projections from the supraoptic nuclei