Phenotypes Associated with This Genotype

Genotype
MGI:3036852

• Allelic Composition: Sim1^tm1Fan/Sim1⁺
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal brown adipose tissue morphology ( J:70586 )

• cells are larger

increased brown adipose tissue amount ( J:70586 )

• mass of brown fat was increased

abnormal white adipose tissue morphology ( J:70586 )

• white adipose tissue cells are histologically normal

increased white adipose tissue amount ( J:70586 )

• increased mass of white fat due to increased number of cells

behavior/neurological

polyphagia ( J:70586 )

• food intake increased around 4-5 weeks of age

• hyperphagia persists over time

growth/size/body

increased body length ( J:70586 )

• heterozygotes have a greater naso-anal length after 4 weeks than do controls

increased susceptibility to weight gain ( J:70586 )

• while growth is normal until 4 weeks of age, weight gain after that time is elevated in both males and females

homeostasis/metabolism

abnormal glucose homeostasis ( J:70586 )

• blood glucose levels were normal at 8 and 24 weeks of age

increased circulating insulin level ( J:70586 )

• although normal at 8 weeks, insulin levels were significantly elevated by 24 weeks of age

• while growth is normal until 4 weeks of age, weight gain after that time is elevated in both males and females

nervous system

abnormal diencephalon morphology ( J:50772 )

• paraventricular nucleus and supraoptic nuclei are hypocellular

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:70586