Phenotypes Associated with This Genotype

Genotype
MGI:3037269

cx3

• Allelic Composition: Csrp3^tm1Crni/Csrp3^tm1Crni; Pln^tm1Egk/Pln^tm1Egk
• Genetic Background: involves: 129S2/SvPas * CF-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiac hypertrophy ( J:58299 )

• indicated by a slight increase in the heart weight/body weight ratio

• heart structure is otherwise normalized compared to conditions in mice homozygous for with Csrp3^Tm1Crni only

• more normal heart size

• normalized myofibrillar organization

• no fibrosis

• normal cardiac chamber dimensions as indicated by echocardiography

increased cardiac muscle contractility ( J:58299 )

• increased contractile properties similar to those of mice homozygous for Pln^tm1Egk only

• normalized left ventricular relaxation and diastolic function

decreased heart rate ( J:58299 )

• slightly decreased relative to wild-type

muscle

increased cardiac muscle contractility ( J:58299 )

• increased contractile properties similar to those of mice homozygous for Pln^tm1Egk only

• normalized left ventricular relaxation and diastolic function

growth/size/body

cardiac hypertrophy ( J:58299 )

• indicated by a slight increase in the heart weight/body weight ratio

• heart structure is otherwise normalized compared to conditions in mice homozygous for with Csrp3^Tm1Crni only

• more normal heart size

• normalized myofibrillar organization

• no fibrosis

• normal cardiac chamber dimensions as indicated by echocardiography