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Phenotypes Associated with This Genotype
Genotype
MGI:3038236
Allelic
Composition
nm3/nm3
Genetic
Background
involves: RIIIS/J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice do not survive past weaning

behavior/neurological
• characteristic choreaform and bradykinetic-type movements typical of Parkinson's Disease

hearing/vestibular/ear
N
• no morphological changes were observed in the inner ear as would be expected in peripheral vestibular diseases

homeostasis/metabolism
N
• blood/serum chemistries did not differ from those of unaffected littermates suggesting no overt pathology in liver, bone, pancreatic, gastrointestinal, endocrine, kidney or hematopoietic systems
• 15-20% reduction in the level of dopamine in the midbrain
• 15-20% reduction in the level of 3,4-dihydroxyphenylacetic acid (DOPAC), the principle dopamine metabolite, in the midbrain

muscle
N
• no morphological changes were observed in the skeletal muscle as would be expected in neuromuscular degenerative diseases

nervous system
N
• no morphological changes were observed in the peripheral nervous system or in the brain including the cerebellum, basal ganglia, and striatum

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease DOID:14330 OMIM:PS168600
J:88298


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory