mortality/aging
• mice do not survive past weaning
|
behavior/neurological
• characteristic choreaform and bradykinetic-type movements typical of Parkinson's Disease
|
bradykinesia
(
J:88298
)
hearing/vestibular/ear
N |
• no morphological changes were observed in the inner ear as would be expected in peripheral vestibular diseases
|
homeostasis/metabolism
N |
• blood/serum chemistries did not differ from those of unaffected littermates suggesting no overt pathology in liver, bone, pancreatic, gastrointestinal, endocrine, kidney or hematopoietic systems
|
• 15-20% reduction in the level of dopamine in the midbrain
• 15-20% reduction in the level of 3,4-dihydroxyphenylacetic acid (DOPAC), the principle dopamine metabolite, in the midbrain
|
muscle
N |
• no morphological changes were observed in the skeletal muscle as would be expected in neuromuscular degenerative diseases
|
nervous system
N |
• no morphological changes were observed in the peripheral nervous system or in the brain including the cerebellum, basal ganglia, and striatum
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Parkinson's disease | DOID:14330 |
OMIM:PS168600 |
J:88298 |