Phenotypes Associated with This Genotype

Genotype
MGI:3038633

• Allelic Composition: Gad2^tm1Miya/Gad2^tm1Miya
• Genetic Background: NOD.129P2-Gad2^tm1Miya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:88785 )

• between 16 and 32 weeks some mutants (7 out of 31) die suddenly from non-diabetic causes most likely related to seizures

behavior/neurological

seizures ( J:88785 )

• seizures induced by mild stimulation are seen in mutants

endocrine/exocrine glands

pancreas inflammation ( J:88785 )

• no difference in the progression of insulitis (infiltration of the islet of Langerhans) is seen between mutants and wild-types by 12 weeks

growth/size/body

decreased body weight ( J:88785 )

• after 4 weeks mild growth retardation is seen in mutants

homeostasis/metabolism

increased circulating glucose level ( J:88785 )

• no difference in incidence of diabetes is seen between female mutants and wild-types

immune system

pancreas inflammation ( J:88785 )

• no difference in the progression of insulitis (infiltration of the islet of Langerhans) is seen between mutants and wild-types by 12 weeks

nervous system

seizures ( J:88785 )

• seizures induced by mild stimulation are seen in mutants

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:88785