Phenotypes Associated with This Genotype

Genotype
MGI:3039434

• Allelic Composition: Sell^tm1Flv/Sell⁺
• Genetic Background: involves: C57BL/6 * NOD

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

pancreas inflammation ( J:88947 )

• inflammation of the islet of Langerhans is seen by 9 weeks in heterozygous and wild-type mice

immune system

pancreas inflammation ( J:88947 )

• inflammation of the islet of Langerhans is seen by 9 weeks in heterozygous and wild-type mice

decreased susceptibility to autoimmune diabetes ( J:88947 )

• the incidence of diabetes (blood glucose >250 mg/dl) in these heterozygotes is decreased as a result of incomplete NOD genetic background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:88974