Analysis Tools
mortality/aging
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• about 60% of transgenic males die suddenly between 6 and 8 months of age
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behavior/neurological
polydipsia
(
J:89252
)
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• transgenic mice drink significantly more than non-transgenic mice
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cardiovascular system
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• transgenic mice have: increased left ventricle/body weight ratios; increased cardiac myocyte cross-sectional area; generalized fibrosis; decreased left ventricular end systolic dimension coupled with increased cardiac function, indicating that these mice have concentric hypertrophy, without ventricular dilation or overt heart failure
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• in mice that die prematurely a prolonged and progressive bradycardia is seen
• transgenics show a significant decrease in heart rate variability compared to wild-type mice
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• transgenic mice have blood pressures more than 25 mmHg higher than wild-type mice
(J:88650)
• transgenic mice have blood pressures more than 25 mmHg higher than wild-type mice
(J:89252)
• administration of an angiotensin II receptor antagonist lowered blood pressure in transgenic mice down to that seen in wild-type mice
(J:89252)
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homeostasis/metabolism
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• serum creatinine is elevated in transgenic mice
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• transgenic mice produce dilute urine but are able to produce concentrated urine following water deprivation
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albuminuria
(
J:89252
)
|
• urine protein/creatinine ratios are elevated and an increase in albumin in the urine of transgenic mice is seen
• administration of an angiotensin II receptor antagonist improved this condition
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immune system
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• vascular, glomerular, and tubointerstitial changes indicative of hypertensive nephrosclerosis are seen in transgenic mice
• cortical sections show inflammatory infiltrates, fibroid necrosis and arterial disruption
• administration of an angiotensin II receptor antagonist ameliorated these pathological changes
|
renal/urinary system
|
• transgenic mice produce dilute urine but are able to produce concentrated urine following water deprivation
|
albuminuria
(
J:89252
)
|
• urine protein/creatinine ratios are elevated and an increase in albumin in the urine of transgenic mice is seen
• administration of an angiotensin II receptor antagonist improved this condition
|
|
• vascular, glomerular, and tubointerstitial changes indicative of hypertensive nephrosclerosis are seen in transgenic mice
• cortical sections show inflammatory infiltrates, fibroid necrosis and arterial disruption
• administration of an angiotensin II receptor antagonist ameliorated these pathological changes
|
growth/size/body
|
• transgenic mice have: increased left ventricle/body weight ratios; increased cardiac myocyte cross-sectional area; generalized fibrosis; decreased left ventricular end systolic dimension coupled with increased cardiac function, indicating that these mice have concentric hypertrophy, without ventricular dilation or overt heart failure
|
