Phenotypes Associated with This Genotype

Genotype
MGI:3039683

• Allelic Composition: Rpsa^tp1/Rpsa^tp1
• Genetic Background: involves: KK

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

heart right ventricle degeneration ( J:87868 )

• calcification as well as massive fibrosis is seen in the right ventricle of these mutants with almost 100% penetrance

• degeneration occurs from week 6 to week 10 after birth and proceeds from the outer part of the right ventricular wall to the inner part

• the left ventricular wall is unaffected

irregular heartbeat ( J:87868 )

• the duration of ventricular muscle depolarization is prolonged indicating a greater susceptibility to arrhythmia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
arrhythmogenic right ventricular dysplasia 5		DOID:0110074	OMIM:604400	J:87868