Phenotypes Associated with This Genotype

Genotype
MGI:3039814

hm1

• Allelic Composition: Rbms1^tm1Hiro/Rbms1^tm1Hiro
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:77893 )

• numbers of homozygous mice born only about half expected

embryonic lethality during organogenesis, incomplete penetrance ( J:77893 )

• deficits in numbers of homozygotes seen as early as E13.5

embryo

embryonic growth retardation ( J:77893 )

• less than 10% of 8 cell embryos develop to a later stage in vitro

decreased embryo size ( J:77893 )

• by E6.5, homozygotes are smaller than wild-type mice

growth/size/body

embryonic growth retardation ( J:77893 )

• less than 10% of 8 cell embryos develop to a later stage in vitro

decreased embryo size ( J:77893 )

• by E6.5, homozygotes are smaller than wild-type mice

homeostasis/metabolism

decreased circulating progesterone level ( J:77893 )

• progesterone levels drop to 6.5% of normal levels at day 2.5 after ovulation

reproductive system

small uterus ( J:77893 )

♀ • uterus development was retarded

♀ • uterus size in homozygous females was smaller than in controls