Phenotypes Associated with This Genotype

Genotype
MGI:3040031

hm2

• Allelic Composition: Arsa^tm1Gie/Arsa^tm1Gie
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal passive avoidance behavior ( J:70355 )

• at 12 months but not at 3 or 6 months, step-through latency is significantly different in mutants compared to wild-type mice

abnormal spatial learning ( J:70355 )

• mutants have longer escape latencies in a water maze test compared to wild-type mice

impaired balance ( J:70355 )

• mutants have impaired performance in the rotating rod test

impaired swimming ( J:70355 )

• swimming speed is significantly reduced in mutants compared to wild-type mice

hyperactivity ( J:70355 )

• at 3, 6, and 12 months of age cage activity is significantly higher in mutant mice