Phenotypes for Dnmt3a Dnmt3b MGI:3040304 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dnmt3a^tm1Enl/Dnmt3a^tm1Enl Dnmt3b^tm1Enl/Dnmt3b^tm1Enl
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3a^tm1Enl mutation (1 available); any Dnmt3a mutation (139 available)
Dnmt3b^tm1Enl mutation (1 available); any Dnmt3b mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:58298 )

• die before E11.5

embryo

incomplete embryo turning ( J:58298 )

• embryos do not undergo embryonic turning

absent somites ( J:58298 )

• by E8.5 embryos lack somites

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
immunodeficiency-centromeric instability-facial anomalies syndrome 1		DOID:0090008	OMIM:242860	J:58298

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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