About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3040601
cx6
Allelic
Composition		 Tcf12tm1Zhu/Tcf12+
Tcf4tm1Zhu/Tcf4+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm1Zhu mutation (0 available); any Tcf12 mutation (75 available)
Tcf4tm1Zhu mutation (1 available); any Tcf4 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:43324 )
• most homozygotes died within two weeks of birth

growth/size/body
postnatal growth retardation ( J:43324 )
• evident after birth

hematopoietic system
decreased pro-B cell number ( J:43324 )
• 50% reduction in the number of pro-B cells

immune system
decreased pro-B cell number ( J:43324 )
• 50% reduction in the number of pro-B cells

nervous system
nervous system phenotype ( J:125313 )
N
• the pontine nucleus develops normally

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory