Phenotypes for Cdkn2a Mxi1 MGI:3040778 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Mxi1^tm1Rdp/Mxi1^tm1Rdp
Genetic Background	involves: 129/Sv * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (66 available)
Mxi1^tm1Rdp mutation (0 available); any Mxi1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:48236 )

• over an observation period of 30 weeks, 80% of Cdkn2a^tm1Rdp mice versus only 44% of double homozygous mutant mice survived and remained tumor-free

• the spectrum of tumor types detected in double homozygous mutant mice was similar to that observed in Cdkn2a^tm1Rdp mice alone (the predominant tumor types being fibrosarcoma and lymphoma)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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