Phenotypes Associated with This Genotype

Genotype
MGI:3041643

• Allelic Composition: Pomc^tm1Sora/Pomc^tm1Sora
• Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

diluted coat color ( J:89244 )

• lighter ventral coat color than that of wild-type

behavior/neurological

polyphagia ( J:89244 )

growth/size/body

obese ( J:89244 )

• increased body weight, relative to controls, when on standard lab diet (4.5% fat)

• significantly higher fat and lean tissue mass relative to controls

• responses to both acute anoretic and chronic administration of peptide-YY_3-36 were similar to those of wild-type

increased susceptibility to diet-induced obesity ( J:89244 )

• a high fat diet augmented the obese phenotype

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:89244 )

• a high fat diet augmented the obese phenotype

decreased circulating thyroxine level ( J:89244 )

decreased circulating corticosterone level ( J:89244 )

• corticosterone was undetectable

decreased oxygen consumption ( J:89244 )

• while oxygen consumption was increased in absolute terms, when corrected for total body mass, resting oxygen consumption was reduced relative to controls

decreased response to leptin ( J:89244 )

• attenuated affect on both food intake and weight loss in response to leptin; observed in older, obese, mice but not in younger, nonobese mice

integument

diluted coat color ( J:89244 )

• lighter ventral coat color than that of wild-type

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:89244