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Phenotypes Associated with This Genotype
Genotype
MGI:3041984
cx2
Allelic
Composition
Grk1tm1Citb/Grk1tm1Citb
Nrltm1Asw/Nrltm1Asw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grk1tm1Citb mutation (0 available); any Grk1 mutation (32 available)
Nrltm1Asw mutation (1 available); any Nrl mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• in situ light-dependent phosphorylation of opsins ex vivo showed that neither S nor M opsin was phosphorylated in the double mutant mouse retina after light exposure
• however, retinas of double mutant mice displayed the same morphology as those of single Nrl mutant mice, and both S and M opsins were expressed in the double mutant retina at equivalent levels to those in single Nrl mutant retina

nervous system
• in situ light-dependent phosphorylation of opsins ex vivo showed that neither S nor M opsin was phosphorylated in the double mutant mouse retina after light exposure
• however, retinas of double mutant mice displayed the same morphology as those of single Nrl mutant mice, and both S and M opsins were expressed in the double mutant retina at equivalent levels to those in single Nrl mutant retina


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory