Phenotypes Associated with This Genotype

Genotype
MGI:3042104

• Allelic Composition: Prkcg^tm1Stl/Prkcg^tm1Stl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:16391 , J:16392 )

N • normal cued conditioning (J:16391)

N • normal behavior (J:16392)

abnormal contextual conditioning behavior ( J:16391 )

• moderate deficit compared to controls

abnormal spatial learning ( J:16391 )

• mild deficit in random platform Morris water maze task, deficit overcome with intensive training, however

• normal spatial learning in both the visible- and hidden-platform Morris water mazes

nervous system

nervous system phenotype ( J:16392 )

N • normal paired-pulse facilitation

N • normal long term depression

N • normal brain anatomy

N • normal baseline synaptic transmission in hippocampal CA1 pyrimidal cells

reduced long-term potentiation ( J:16392 )