Phenotypes Associated with This Genotype

Genotype
MGI:3042606

• Allelic Composition: Prop1^df/Prop1^df
• Genetic Background: STOCK Prop1^df

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:12169 )

N • testes nearly normal

absent somatotrophs ( J:7211 )

• pituitary gland lacked identifiable somatotropes

decreased thyrotroph cell number ( J:12169 )

• reduced numbers of thyrotropic hormone producing cells

small adenohypophysis ( J:12169 )

• anterior pituitary reduced in size

small thyroid gland ( J:12169 )

• follicles were small and some tissue was not organized into follicles

absent corpus luteum ( J:12169 )

♀

absent tertiary ovarian follicles ( J:12169 )

♀ • large follicles absent

small ovary ( J:12169 )

♀

growth/size/body

proportional dwarf ( J:36967 )

• daily i.p. injections of bovine growth hormone for ~ 6 weeks produced animals of nearly normal size

homeostasis/metabolism

decreased circulating prolactin level ( J:5900 )

• deficient

decreased circulating growth hormone level ( J:6340 )

• deficient

decreased circulating thyroid-stimulating hormone level ( J:6340 )

• deficient

decreased follicle stimulating hormone level ( J:5900 )

• males, in the pituitary

decreased circulating follicle stimulating hormone level ( J:5900 )

• males

• treatment with ovine prolactin or prolactin producing grafts, resulted in increased FSH levels

decreased luteinizing hormone level ( J:5900 )

• males, in the pituitary

reproductive system

absent corpus luteum ( J:12169 )

♀

absent tertiary ovarian follicles ( J:12169 )

♀ • large follicles absent

small ovary ( J:12169 )

♀

female infertility ( J:36967 )

♀ • still infertile after treatment with bovine growth hormone

male infertility ( J:36967 )

♂ • became fertile after treatment with bovine growth hormone

nervous system

absent somatotrophs ( J:7211 )

• pituitary gland lacked identifiable somatotropes

decreased thyrotroph cell number ( J:12169 )

• reduced numbers of thyrotropic hormone producing cells

small adenohypophysis ( J:12169 )

• anterior pituitary reduced in size

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypopituitarism		DOID:9406	OMIM:221750 OMIM:262600 OMIM:262700 OMIM:613038 OMIM:613986	J:5900 , J:6340 , J:7211 , J:12169 , J:36967