Analysis Tools
mortality/aging
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• most homozygous mutant mice died during the first few days after birth
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cardiovascular system
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• 82% of mutant mice exhibited malpositioning of heart outflow tracts
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|
• in wild-type mice, the aorta is located dorsal and to the left of the pulmonary artery; in contrast, the mutant aorta connected to the right ventricle and emerged from the heart in a ventral position and to the right of the pulmonary artery
• in wild-type mice, the pulmonary artery is always connected to the right ventricle; in mutant mice, the pulmonary artery connected to either the left or the right ventricle
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• one out of seven mutant mice displayed double outlet right ventricle
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• the pulmonary artery is connected to either the left or the right ventricle
• the aorta is connected to the right ventricle and emerged from the heart in a ventral position and to the right of the pulmonary artery
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dextrocardia
(
J:58530
)
|
• in mutant mice, the apex of the heart pointed to the right (30%) or left (70%) side of the body; in wild-type mice, the apex of the heart pointed towards the left side of the body
• the position of the heart was independent of the position of the stomach; however, no looping abnormalities were observed at E8.5
|
common atrium
(
J:58530
)
|
• mutant mice displayed a common atrial chamber, as opposed to a left and a right atrium
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digestive/alimentary system
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• the stomach of mutant mice was located on either the left side (45%) or the right side (55%); in wild-type mice, the stomach is located on the left
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growth/size/body
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• the stomach of mutant mice was located on either the left side (45%) or the right side (55%); in wild-type mice, the stomach is located on the left
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• in contrast to wild-type, both the right and left lungs of mutant mice had four lobes
• histological analysis confirmed loss of asymmetrical bronchi and branching patterns
• notably, mutant lungs diplayed no major tissue abnormalities
|
hematopoietic system
small spleen
(
J:58530
)
|
• the mutant spleen was small and abnormally shaped relative to wild-type
|
immune system
small spleen
(
J:58530
)
|
• the mutant spleen was small and abnormally shaped relative to wild-type
|
respiratory system
|
• in contrast to wild-type, both the right and left lungs of mutant mice had four lobes
• histological analysis confirmed loss of asymmetrical bronchi and branching patterns
• notably, mutant lungs diplayed no major tissue abnormalities
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| dextro-looped transposition of the great arteries | DOID:0060770 |
OMIM:608808 |
J:58530 | |
| double outlet right ventricle | DOID:6406 |
OMIM:217095 |
J:58530 | |
| right atrial isomerism | DOID:0060856 |
OMIM:208530 |
J:58530 | |
