Phenotypes Associated with This Genotype

Genotype
MGI:3043188

cx3

• Allelic Composition: Slit1^tm1.1Matl/Slit1^tm1.1Matl; Slit2^tm1Matl/Slit2^tm1Matl; Slit3^tm1.1Dor/Slit3^tm1.1Dor
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon guidance ( J:89780 )

• at E12.5 commissural axons appear disorganized as they exit the floor plate lacking the typical bundled morphology

• at E12.5 more commissural axons stall and fail to exit the floor plate (78% versus 28% in controls) or recross the floor plate (~20% versus 0% in controls; controls in this study were Slit1^tm1.1Matl homozygotes)

abnormal spinal cord lateral column morphology ( J:89780 )

• the lateral funiculus (white matter tract) is significantly thinner in triple homozygous mutants compared to controls

cellular

abnormal axon guidance ( J:89780 )

• at E12.5 commissural axons appear disorganized as they exit the floor plate lacking the typical bundled morphology

• at E12.5 more commissural axons stall and fail to exit the floor plate (78% versus 28% in controls) or recross the floor plate (~20% versus 0% in controls; controls in this study were Slit1^tm1.1Matl homozygotes)