Phenotypes for Slit1 Slit2 Slit3 MGI:3043191 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Slit1^tm1.1Matl/Slit1^tm1.1Matl Slit2^tm1Matl/Slit2^tm1Matl Slit3^tm1.1Dor/Slit3⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit1^tm1.1Matl mutation (0 available); any Slit1 mutation (71 available)
Slit2^tm1Matl mutation (2 available); any Slit2 mutation (88 available)
Slit3^tm1.1Dor mutation (1 available); any Slit3 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon guidance ( J:89780 )

• at E12.5 commissural axons occasionally recross the floor plate, this is never seen in controls

abnormal spinal cord ventral commissure morphology ( J:89780 )

• the ventral commissure (bundle of nerve fibers passing from one side to the other in the spinal cord) appears thicker compared to controls

abnormal spinal cord lateral column morphology ( J:89780 )

• the ventral funiculus (white matter tract) appears reduced in mutants compared to controls

cellular

abnormal axon guidance ( J:89780 )

• at E12.5 commissural axons occasionally recross the floor plate, this is never seen in controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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