Phenotypes Associated with This Genotype

Genotype
MGI:3043596

• Allelic Composition: Ercc5^tm2Shm/Ercc5^tm2Shm
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:89911 )

N • homozygous mice have a normal lifespan

growth/size/body

growth/size/body region phenotype ( J:89911 )

N • homozygous mice do not display any growth abnormalities

homeostasis/metabolism

phototoxicity ( J:89911 )

• cells from homozygous mutants are more sensitive to UV light than cells from wild-type mice but not as sensitive as cells from Ercc5^tm1Shm

• UV induced DNA lesions are partially removed in homozygous mutant cell

integument

phototoxicity ( J:89911 )

• cells from homozygous mutants are more sensitive to UV light than cells from wild-type mice but not as sensitive as cells from Ercc5^tm1Shm

• UV induced DNA lesions are partially removed in homozygous mutant cell

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
xeroderma pigmentosum group G		DOID:0110849	OMIM:278780	J:89911