Analysis Tools
mortality/aging
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• the 50% survival age is 10.3 months
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neoplasm
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• 65.7% of mice develop tumors, predominantly lymphoma (37.1%), ovarian tumors (34.8%), and lung adenomas (31.4%)
• 75% of lung tumors have a G to T mutation in codon 12 of Kras2
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• 34.8% of mutants develop ovarian tumors after 12 months of age
• 4 of 5 ovarian tumors are bilateral
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• most ovarian tumors are hemangiomas which can result in lethal hemorrhaging
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• observe in 37.1% of mice, with extensive lymphoma burdens in most organs such as the lung, heart, liver, spleen, kidneys, and lymph nodes
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• 31.4% of mutants develop lung tumors after 12 months of age
• 78.6% of older mutants that live more than 12 months develop lung tumors
• lung tumors are solitary and white nodules with a 1-10 mm diameter
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• most lung tumors are adenomas, seen in 31.4% of mutants
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endocrine/exocrine glands
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• 34.8% of mutants develop ovarian tumors after 12 months of age
• 4 of 5 ovarian tumors are bilateral
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reproductive system
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• 34.8% of mutants develop ovarian tumors after 12 months of age
• 4 of 5 ovarian tumors are bilateral
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respiratory system
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• 31.4% of mutants develop lung tumors after 12 months of age
• 78.6% of older mutants that live more than 12 months develop lung tumors
• lung tumors are solitary and white nodules with a 1-10 mm diameter
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• most lung tumors are adenomas, seen in 31.4% of mutants
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