Phenotypes for Msh2 Mutyh Ogg1 MGI:3043936 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Msh2^tm1Mak/Msh2^tm1Mak Mutyh^tm1Jhmi/Mutyh^tm1Jhmi Ogg1^tm1Tld/Ogg1^tm1Tld
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2^tm1Mak mutation (1 available); any Msh2 mutation (95 available)
Mutyh^tm1Jhmi mutation (0 available); any Mutyh mutation (36 available)
Ogg1^tm1Tld mutation (0 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:89742 )

• the 50% survival age is 4.3 months and all mutants die within 10.3 months

neoplasm

increased tumor incidence ( J:89742 )

• 86.7% of mice develop tumors, predominantly lymphoma (76.7%) with some incidence of lung adenoma (10%)

increased lung adenoma incidence ( J:89742 )

• observe in 10% of mice

increased lymphoma incidence ( J:89742 )

• observe in 76.7% of mice

respiratory system

increased lung adenoma incidence ( J:89742 )

• observe in 10% of mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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