Phenotypes Associated with This Genotype

Genotype
MGI:3043953

cx4

• Allelic Composition: Msh2^tm1Mak/Msh2⁺; Mutyh^tm1Jhmi/Mutyh^tm1Jhmi; Ogg1^tm1Tld/Ogg1^tm1Tld
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:89742 )

• the 50% survival age is around 10 months

neoplasm

increased tumor incidence ( J:89742 )

• 76.9% of mice develop tumors, including ovarian tumors (57.6%), lung adenomas (35.9%), lung adenocarcinoma (61.3%), lymphoma (26.9%)

increased ovary tumor incidence ( J:89742 )

♀ • in 57.6% of mice, with the earliest onset at 5 months of age

increased lung adenoma incidence ( J:89742 )

• observe in 35.9% of mice

increased lymphoma incidence ( J:89742 )

• observe in 26.9% of mice

increased lung adenocarcinoma incidence ( J:89742 )

• 61.3% of mutants develop lung adenocarcinomas after 10.6 months of age

respiratory system

increased lung adenoma incidence ( J:89742 )

• observe in 35.9% of mice

increased lung adenocarcinoma incidence ( J:89742 )

• 61.3% of mutants develop lung adenocarcinomas after 10.6 months of age

endocrine/exocrine glands

increased ovary tumor incidence ( J:89742 )

♀ • in 57.6% of mice, with the earliest onset at 5 months of age

reproductive system

increased ovary tumor incidence ( J:89742 )

♀ • in 57.6% of mice, with the earliest onset at 5 months of age