Phenotypes Associated with This Genotype

Genotype
MGI:3044184

• Allelic Composition: App^tm1Ini/App⁺
• Genetic Background: involves: C57BL/6 * CBA * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:90296 )

• moderately accelerated mortality among females only after 56 weeks of age

• by 125 weeks of age survival was about 48.5% as opposed to 62.2% in controls

behavior/neurological

abnormal learning/memory/conditioning ( J:90296 )

abnormal long-term object recognition memory ( J:90296 )

• slower at a water finding test at 27 months of age, no difference when tested at 6 months of age

abnormal spatial learning ( J:90296 )

♀ • females were slower at spatial memory acquisition

abnormal locomotor behavior ( J:90296 )

♂ • males were quicker to begin exploration in open field tests

increased locomotor activity ( J:90296 )

♂ • overall locomotor activity was increased in males

nervous system

amyloid beta deposits ( J:90296 )

• the abundance of the longer form of beta amyloid was significantly increased relative to the shorter form

abnormal telencephalon morphology ( J:90296 )

• no signs of neuritic plaque or neurofibrillar tangle formation

homeostasis/metabolism

amyloid beta deposits ( J:90296 )

• the abundance of the longer form of beta amyloid was significantly increased relative to the shorter form

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:90296