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Phenotypes Associated with This Genotype
Genotype
MGI:3044416
cx3
Allelic
Composition		 Mitfmi-ew/Mitfmi-ew
Tfe3tm1Est/Tfe3tm1Est
Genetic
Background		 either: (involves: 129/Sv * 129S1/Sv * C57BL/6Bn * NAW) or (involves: 129S1/Sv * C57BL/6Bn * C57BL/6J * NAW)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-ew mutation (1 available); any Mitf mutation (74 available)
Tfe3tm1Est mutation (1 available); any Tfe3 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:89821 )
• mice die within 3 weeks of birth

pigmentation
absent coat pigmentation ( J:89821 )
• mice have a white coat; similar to Mitfmi-ew/mi-ew mice

craniofacial

growth/size/body
delayed tooth eruption ( J:89821 )
decreased body weight ( J:89821 )

skeleton
abnormal osteoclast morphology ( J:89821 )
• small osteoclasts
osteopetrosis ( J:89821 )
• severe

vision/eye
microphthalmia ( J:89821 )
• similar to Mitfmi-ew/mi-ew mice

hematopoietic system
abnormal osteoclast morphology ( J:89821 )
• small osteoclasts

immune system
abnormal osteoclast morphology ( J:89821 )
• small osteoclasts

integument
absent coat pigmentation ( J:89821 )
• mice have a white coat; similar to Mitfmi-ew/mi-ew mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory