Phenotypes Associated with This Genotype

Genotype
MGI:3044705

• Allelic Composition: Wfs1^tm1Yoka/Wfs1^tm1Yoka
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:90420 )

• the number of beta cells decreases with age in homozygous mice probably as a result of increased beta cell susceptibility to apoptosis

• this effect is more prominent on a [(129/Sv x C57BL/6) x C57BL/6]F2 background than on a C57BL/6 background

increased glucagon secretion ( J:90420 )

• glucagon positive cells and pancreatic glucagon content are increased in homozygous mice at 36 weeks of age

homeostasis/metabolism

increased glucagon secretion ( J:90420 )

• glucagon positive cells and pancreatic glucagon content are increased in homozygous mice at 36 weeks of age

increased circulating glucose level ( J:90420 )

• blood glucose levels started to rise by 16 weeks of age on a [(129/Sv x C57BL/6) x C57BL/6]F2 background but not on a C57BL/6 background

• homozygous mice developed diabetes by 36 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Wolfram syndrome 1		DOID:0110629	OMIM:222300	J:90420